A tavaszi szemeszter első intézeti szemináriumi előadására február 10-én kerül sor a könyvtárunkban (EOK, 2. emelet). Kezdés délután 1 órakor.

 

Vendégünk, Tomáš Křížek, Prágából érkezik, a Károly Egyetem Analitikai Kémia Tanszékéről, a CEEPUS program keretében.

 

Előadásának címe: Application of capillary electrophoresis in controlled drug release studies

 

Absztrakt: Polymer nanocarriers represent one of the major approaches in the development of targeted drug delivery systems. In vitro monitoring of drug release is one of the crucial steps in the early development of such formulations, with HPLC being considered the method of choice for these purposes.

Nevertheless, polymer carriers usually cannot be injected into the HPLC system as they can irreversibly adsorb to the stationary phase or other components of the system, causing deterioration of separation efficiency or even column clogging. A liquid-liquid or solid-phase extraction step is thus necessary. On

the contrary, the open-tubular columns used in capillary electrophoresis can tolerate problematic sample matrices, and eventually adsorbed polymers can be washed out using a strong base, acid, or organic solvent. In this lecture, general considerations on the advantages and limitations of capillary electrophoresis as a technique for monitoring drug release will be discussed, followed by examples of successful applications to the separation and determination of hydrophilic drugs released from polymer carriers.